￭ 학력 및 경력

1996-2002 학사 (경기대학교 생물학과)
2002-2004 석사 (서울대학교 수의과대학)
2005-2011 박사 (University of British Columbia, UBC)
2012-2013 선임연구원 (서울대학교 수의과대학)
2013-2014 연구조교수 (서울대학교 수의과대학)
2014-현재 조교수 (가천대학교 의예과(분자의학))

 

 

 

￭소개

 

최근 들어 성체줄기세포를 활용한 퇴행성 뇌질환, 간경화, 뉴마티스 관절염 등과 같은 여러 난치성 질환에 대한 세포 치료 모델로 주목 받고 있음. 뿐만 아니라 본 연구실에서는 줄기세포의 분화 및 노화를 조절하는 표적 유전자를 발굴하여 체외에서 줄기세포의 기능을 조절하는데 기초 연구도 병행하고 있음.

 

 

￭키워드

 

줄기세포, 난치성질환, 분화, 노화

 

 

￭최근연구업적(2014-현재) (최근5년간의주요연구실적)

 

 

1. Park SR, Kim SR, Park CH, Ha SY, Hong IS, Lee HY. Sonic hedgehog (SHH), a novel endogenous damage signal, activates multiple beneficial functions of human endometrial stem cells. Mol Ther. 2019 Dec 5, IF 8.402 DOI:https://doi.org/10.1016/j.ymthe.2019.11.024 [공동교신저자]

 

2. Cho A, Park SR, Kim SR, Nam S, Lim S, Park CH, Lee HY, Hong IS. An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2. Mol Ther. 2019 Jul 3;27(7):1286-1298. IF 8.402

 

3. Lee NH, Park SR, Lee JW, Lim S, Lee SH, Nam S, Kim DY, Hah SY, Hong IS, Lee HY. SERPINB2 Is a Novel Indicator of Cancer Stem Cell Tumorigenicity in Multiple Cancer Types. Cancers (Basel). 2019 Apr 8;11(4). IF 6.162

 

4. Park SR, Cho A, Kim JW, Lee HY, Hong IS. A Novel Endogenous Damage Signal, CSF-2, Activates Multiple Beneficial Functions of Adipose Tissue-Derived Mesenchymal Stem Cells. Mol Ther. 2019 Jun 5;27(6):1087-1100. IF 8.402

 

5. Seo Y, Kim HS, Hong IS. Stem Cell-Derived Extracellular Vesicles as Immunomodulatory Therapeutics. Stem Cells Int. 2019 Feb 26;2019:5126156. IF 3.902

 

6. Park SR, Cho A, Park ST, Park CH, Lim S, Jin M, Lee HY, Hong IS. Double-edged sword of gonadotropin-releasing hormone (GnRH): A novel role of GnRH in the multiple beneficial functions of endometrial stem cells. Cell Death Dis. 2018 Aug 1;9(8):828. IF 5.959

 

7. Lee NH, Cho A, Park SR, Lee JW, Sung Taek P, Park CH, Choi YH, Lim S, Baek MK, Kim DY, Jin M, Lee HY, Hong IS. SERPINB2 is a novel indicator of stem cell toxicity. Cell Death Dis. 2018 Jun 20;9(7):724. IF 5.959

 

8. Park SR, Kim HJ, Yang SR, Park CH, Lee HY, Hong IS. A novel endogenous damage signal, glycyl tRNA synthetase, activates multiple beneficial functions of mesenchymal stem cells. Cell Death Differ. 2018 Nov;25(11):2023-2036. IF 8.086

 

9. Park SR, Kim JW, Jun HS, Roh JY, Lee HY, Hong IS. Stem Cell Secretome and Its Effect on Cellular Mechanisms Relevant to Wound Healing. Mol Ther. 2018 Feb 7;26(2):606-617. IF 8.402

 

10. Lee HY, Hong IS. Double-edged sword of mesenchymal stem cells: Cancer-promoting versus therapeutic potential. Cancer Sci. 2017 Oct;108(10):1939-1946. IF 4.751

 

11. Hong IS. Stimulatory versus suppressive effects of GM-CSF on tumor progression in multiple cancer types. Exp Mol Med. 2016 Jul 1;48(7):e242. IF 4.743

 

12. Dong HJ, Jang GB, Lee HY, Park SR, Kim JY, Nam JS, Hong IS. The Wnt/β-catenin signaling/Id2 cascade mediates the effects of hypoxia on the hierarchy of colorectal-cancer stem cells. Sci Rep. 2016 Mar 11;6:22966. IF 4.011

 

13. Hong IS, Jang GB, Lee HY, Nam JS. Targeting cancer stem cells by using the nanoparticles. Int J Nanomedicine. 2015 Sep 10;10(Spec Iss):251-60. IF 4.471

 

14. Jang GB, Kim JY, Cho SD, Park KS, Jung JY, Lee HY, Hong IS, Nam JS. Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype. Sci Rep. 2015 Jul 23;5:12465 IF 4.011

 

15. Jang GB*, Hong IS*, Kim RJ, Lee SY, Park SJ, Lee ES, Park JH, Yun CH, Chung JU, Lee KJ, Lee HY, Nam JS. Cancer Res. 2015 Apr 15;75(8):1691-702. IF 8.378[Co-first author].