참여교수 및 연구
- 참여교수 및 연구
- 참여교수 개별소개
참여교수 개별소개
- 소속 및 직위
- 소속: 의예과 , 직위: 부교수
- 실험실명
- 기능단백체 네트워크연구실
- 연구분야
- 단백질학/재생의학
- 연구실위치
- 암당뇨연구원 N504호
- 전공분야
- 해부학, 신경질환, 대사질환
- +82-32-899-6511
- khbyun1@gachon.ac.kr
- +82-32-899-6518
￭학력 및 경력
2006 의학박사 (해부학), 제주대학교
2006-2010 박사 후 연구원, 가천대학교, 이길여암당뇨연구원
2011-현재 부교수, 가천대학교
￭소개
본 연구실에서는 혈관, 연골, 염증 및 신경질환 치료를 위한 포괄적 개념의 중개 연구를 수행하고 있다. 줄기세포에 유전자 편집, 나노과학, 기능단백체학 등의 기술을 이용하여 신개념의 차세대줄기세포치료제의 개발을 주된 목표로 삼고 다양한 수준에서의 재생의학 연구를 수행하고 있다. 뿐만 아니라 역분화줄기세포 및 배아줄기세포를 이용하여 환자모사 세포제작, 바이오마커 개발 및 분화연구를 수행하고 있으며, 시스템생물학을 이용한 기능단백체 분석, 실시간 분자이미징등의 기술을 활용하여 치료제의 메커니즘 및 기능을 연구하고있다.
￭키워드
재생의학, 줄기세포, 유전자 편집, 차세대줄기세포, 기능단백체, 환자모사세포, 실기간 분자이미징, 시스템생물학
￭최근 연구업적(2013-현재) (최근 5년간의 주요연구실적)
1. Protective Effect of Pyrogallol-Phloroglucinol-6,6-Bieckol from Ecklonia cava on Monocyte-Associated Vascular Dysfunction. (2018) Mar Drugs. 9;16(11).
2. Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation. (2018) Cell Report. 23;25(4):934-946.
3. Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo (2018) Autophage 14(6):1011-10274.
4. sRAGE prolonged stem cell survival and suppressed RAGE-related inflammatory cell and T lymphocyte accumulations in an Alzheimer's disease model (2018) Biochemical and Biophysical Research Communications 1;495(1):807-813.5.
5. The Effect of Human Adipose Tissue–Derived Mesenchymal Stem Cells in Rat’s Subglottic Stenosis Model (2018) Ann Otol Rhinol Laryngol. 127(1):5-12.
6. MicroRNA-340 inhibits the proliferation and promotes the apoptosis of colon cancer cells by modulating REV3L (2018) Oncotarget 26;9(4):5155-5168.
7. Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy (2018) stem cell reports 13;10(3):848-859.
8. 6. Protection against RAGE-mediated neuronal cell death by sRAGE-secreting human mesenchymal stem cells in 5xFAD transgenic mouse model (2017) Brain, Behavior, and Immunity 66:347-358.
9. Advanced glycation end-products produced systemically and by macrophages: A common contributor to inflammation and degenerative diseases. (2017) Pharmacology & therapeutics 177:44-55.
10. Advanced glycation end-product (AGE)-albumin from activated macrophage is critical in human mesenchymal stem cells survival and post-ischemic reperfusion injury. (2017) Scientific Reports 14;7(1):11593.
11. Age dependent accumulation patterns of advanced glycation end product receptor (RAGE) ligands and binding intensities between RAGE and its ligands differ in the liver, kidney, and skeletal muscle.(2017) Immunity and Ageing 5;14:12
12. Kang WC Improved early risk stratification of patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention using a combination of serum soluble ST2 and NT-proBNP (2017) Plos One 10;12(8):e0182829
13. Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics. (2016) Int J Nanomedicine 23(10) 281-292
14. Age-related accumulation of advanced glycation end-products-albumin, S100β, and the expressions of advanced glycation end product receptor differ in visceral and subcutaneous fat. (2016) Biochem Biophys Res Commun. 19;477(2):271-276
15. Increasing injection frequency enhances the survival of injected bone marrow derived mesenchymal stem cells in a critical limb ischemia animal model. (2016) Korean J Physiol Pharmacol. 20(6):657-667
16. Apelin-13 infusion salvages the peri-infarct region to preserve cardiac function after severe myocardial injury. (2016) Int J Cardiol. 1(222):361-367
17. Intravenously Infused F3.Olig2 Improves Memory Deficits via Restoring Myelination in the Aged Hippocampus Following Experimental Ischemic Stroke. (2016) Cell Transplantation 13;25(12):2129-2144