Gene expression, Epigenetics, Stem cell,Embryo development, Cell fate decision, Single cell research, Computational analysis, Developing multiomics/sequencing technology

 Our team’s research goal is to understand how cell decides its fate to be specific cell types, and apply cell-fate decision mechanisms to modulate cell states in various biological systems involving development and disease models. With recent technological advances of genomics and single cell biology, we arefosteringto understand heterogeneous cell states in biological systems, and demonstrating cell fate decision trajectories involving where each cell comes from and progress into. We are pursuing to develop new single cell technology capturing various cellular materials (information) and recording cell states from same single cell, andwith this cellular information, wewill develop analysis algorithms to combine multi-layered information, inferring cell hierarchy in development and disease models. It will allow us to reconstruct in silico cell architectures representing cell’s origin, current state and inferred future state that would be important models to support correct diagnosis of disease sates and further to cure it by targeting founders and drivers of disordered cells.

 https://sites.google.com/view/ikim-lcfd