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  In vivo animal MRS core
The In vivo animal MRS core develops magnetic resonance spectroscopy (MRS) and imaging (MRI) methods for quantitative analyses of time-dependent changes in the concentrations of a variety of metabolites in vivo. These methods are then applied to elucidating the etiologies, and facilitating the treatment, of metabolic syndromes such as obesity and type 2 diabetes.
 
The principle functions of the Core are as follows
1H-MRS
Estimation of fat content in the liver and muscle
Development of spectral editing methods for quantifying metabolites associated with metabolic syndromes in the brain, liver and muscle
13C-MRS Estimation of the rate of glycogen synthesis in the liver and muscle in association with insulin resistance
Examination of the oxidative activity of mitochondria via estimation of TCA cycle flux
31P-MRS Examination of energy metabolism in the liver and muscle in relation to insulin resistance
MRI Development of multipoint water-fat separation MRI methods for more efficient quantification of fat in the liver, muscle, heart and whole body
 
Equipments

9.4 T animal NMR spectrometer with 4 receiver channels (Bruker Biospec 94/20 USR)
 
 
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